4-Amino-6,7-dimethoxyquinazol-2-yl alkylenediamines

Details 4-Amino-6,7-dimethoxyquinazol-2-yl alkylenediamines 4-Amino-6,7-dimethoxyquinazol-2-yl alkylenediamines

1979-12-10

1982-02-09

Coughlan, Jr., Paul M.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544291, A61K 31505, C07D23995

Patent

active

043150071

ABSTRACT:
Alkylenediamine amides corresponding to the general formula (I) ##STR1## in which R.sub.1 and R.sub.2 each represent, independently of one another, a hydrogen atom, an alkyl having 1 to 4 carbon atoms or the benzyl radical, n is equal to 2, 3 or 4 and R represents either a cycloalkyl radical having 3 to 6 carbon atoms, or a radical ##STR2## in which m is 0, 1 or 2, ##STR3## in which m is 0, 1 or 2 and p is 0, 1 or 2, and also their addition salts with pharmaceutically acceptable acids. These compounds may be prepared by reacting an aminoamide ##STR4## with a 4-amino-2-halogeno-6,7-dimethoxyquinazoline (II). The compounds are useful in treating cardiovascular disorders, and pharmaceutical compositions containing the compounds are also claimed.

REFERENCES:
patent: 3635979 (1972-01-01), Hess
patent: 4026894 (1977-05-01), Winn et al.
patent: 4060615 (1977-11-01), Matier et al.

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