4-Amino-6,7-dimethoxy-2-(4-heteroaryl-piperazino)quinazoline ant

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Bacterium or component thereof or substance produced by said...

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424246, 42424856, 424249, 544 62, 544113, 544119, 544198, 544207, 544209, 544212, 544238, 544253, 544284, 544291, 544292, 544295, 544319, 544334, A61K 31505, A61K 3138, C07D40314, C07D41714

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044354010

ABSTRACT:
2,4-Diaminoquinazoline compounds of the formula ##STR1## or a pharmaceutically acceptable salt thereof wherein R is a pyrimidinyl, pyrazinyl, pyridazinyl or triazinyl group linked to the piperazine ring by one of its carbon atoms, and optionally substituted by hydroxy, halogen, alkyl, aralkyl, alkoxy, aralkoxy, alkylthio, aryl, aryloxy and certain amino groups; their use as an antihypertensive agent and pharmaceutical compositions containing them.

REFERENCES:
patent: 3511836 (1970-05-01), Hess
patent: 3517005 (1970-06-01), Cronin et al.
patent: 3669968 (1972-06-01), Hess
patent: 3900476 (1975-08-01), Renis et al.
patent: 4161595 (1979-07-01), Kaplan
patent: 4171363 (1979-10-01), Crenshaw et al.
patent: 4188390 (1980-02-01), Campbell
patent: 4287341 (1981-09-01), Hess et al.
patent: 4351832 (1982-09-01), Rakhit et al.
MIMS, Feb. 1983, p. 74.

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