4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside...

Details 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside... 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside...

2006-08-29

2006-08-29

McKenzie, Thomas C. (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

active

07098334

ABSTRACT:
The invention provides a compound of the formula:wherein A is selected from N, CH and CR; R is selected from halogen, optionally substituted alkyl, aralkyl and aryl, OH, NH2, NHR1, NR1R2and SR3; R1, R2and R3are each optionally substituted alkyl, aralkyl or aryl groups; B is selected from NH2and NHR4; R4is an optionally substituted alkyl, aralkyl or aryl group; X is selected from H, OH and halogen; Z is selected from H, Q, SQ and OQ; Q is an optionally substituted alkyl, aralkyl or aryl group; or a tautomer, a pharmaceutically acceptable salt, an ester, or a prodrug thereof; with the proviso that the stereochemistry of the aza-sugar moiety is D-ribo or 2′-deoxy-D-erythro-; pharmaceutical compositions comprising said compound; and methods of treatment using said compound.

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