4-Amino-5-oxo-8-phenyl-5H-pyrido(2,3-D) pyrimidine...

Details 4-Amino-5-oxo-8-phenyl-5H-pyrido(2,3-D) pyrimidine... 4-Amino-5-oxo-8-phenyl-5H-pyrido(2,3-D) pyrimidine...

2005-10-20

2010-06-29

Wilson, James O (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S249000, C544S122000, C544S279000

Reexamination Certificate

active

07745434

ABSTRACT:
Compounds of the formula (I), in which R6, R7, R8, R9, Het1, X and X′ have the meanings indicated in claim1, are inhibitors of tyrosine kinases, in particular TIE-2, and Raf kinases and can be employed, inter alia, for the treatment of tumours.

REFERENCES:
patent: 6217860 (2001-04-01), Woo et al.
patent: 7547695 (2009-06-01), Hoelzemann et al.
patent: WO 03/027110 (2003-04-01), None
patent: WO 2004/039774 (2004-05-01), None
patent: WO 2004/085436 (2004-10-01), None
patent: WO 2005/047283 (2005-05-01), None
Wolff, et. al., “Burger's Medicinal Chemistry and Drug Discovery,” 5th Ed. Part 1, pp. 975-977 (1995).
Banker, et. al., Modern Pharmaceuticals, (1996) p. 596.
Dorwald F. A. Side Reactions in Organic Synthesis, 2005, Wiley: VCH, Weinheim p. IX of Preface.

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