Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-06-14
2005-06-14
Rao, Deepak (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S275000, C544S122000, C544S323000, C544S324000
Reexamination Certificate
active
06906065
ABSTRACT:
Compounds of formula (I) wherein: R1is halo, nitro, cyano, hydroxy, amino, carboxy, carbamoyl, mercapto, C1-6alkyl, C2-6alkenyl or C2-6alkynyl; p is 0-4; wherein the values of R1may be the same or different; R2is sulphamoyl or a group B-E- ; wherein B is optionally substituted as defined within and is selected from C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-8cycloalkyl, C1-6alkyl, phenyl, a heterocyclic group, phenylC1-6alkyl or (heterocyclic group)C1-6alkyl; E is C(O)—, N(Ra)C(O)—, —C(O)N(Ra)—, —S(O)r—, —SO2N(Ra)— or —N(Ra)SO2—; wherein Rais hydrogen or C1-6alkyl optionally substituted as defined within and r is 1-2; q is 0-2; wherein the values of R2may be the same or different; and wherein p+q=1-5; or a pharmaceutically acceptable salt or an in vivo hydrolysable ester thereof are described. Processes for their manufacture and their use as inhibitors of cell cycle kinases, particularly CDK2, CDK4 and/or CDK6 are also described
REFERENCES:
patent: 4983608 (1991-01-01), Effland et al.
patent: 5516775 (1996-05-01), Zimmermann et al.
patent: 5521184 (1996-05-01), Zimmermann
patent: 5610303 (1997-03-01), Kimura et al.
patent: 5739143 (1998-04-01), Adams et al.
patent: 5859041 (1999-01-01), Liverton et al.
patent: 5985877 (1999-11-01), Dionne et al.
patent: 2231765 (1998-09-01), None
patent: 0 135 472 (1985-03-01), None
patent: 0 363 002 (1990-04-01), None
patent: 0 379 806 (1990-08-01), None
patent: 0 564 409 (1993-10-01), None
patent: 0 945 443 (1999-09-01), None
patent: 91/18887 (1991-12-01), None
patent: 92/20642 (1992-11-01), None
patent: 95/09847 (1995-04-01), None
patent: 95/09851 (1995-04-01), None
patent: 95/09852 (1995-04-01), None
patent: 95/09853 (1995-04-01), None
patent: 95/15952 (1995-06-01), None
patent: 96/05177 (1996-02-01), None
patent: 96/28427 (1996-09-01), None
patent: 96/33980 (1996-10-01), None
patent: 96/40143 (1996-12-01), None
patent: 97/19065 (1997-05-01), None
patent: 97/35856 (1997-10-01), None
patent: 97/40017 (1997-10-01), None
patent: 97/44326 (1997-11-01), None
patent: 97/47618 (1997-12-01), None
patent: 98/11095 (1998-03-01), None
patent: 98/16230 (1998-04-01), None
patent: 98/18782 (1998-05-01), None
patent: 98/25619 (1998-06-01), None
patent: 98/33798 (1998-08-01), None
patent: 98/41512 (1998-09-01), None
patent: 98/54093 (1998-12-01), None
patent: 98/56788 (1998-12-01), None
patent: 99/01136 (1999-01-01), None
patent: 99/32121 (1999-01-01), None
patent: 99/18096 (1999-04-01), None
patent: 99/18942 (1999-04-01), None
patent: 99/31073 (1999-06-01), None
patent: 99/41253 (1999-08-01), None
patent: 99/50250 (1999-10-01), None
patent: 99/50251 (1999-10-01), None
patent: 00/12485 (2000-03-01), None
patent: 00/12486 (2000-03-01), None
patent: 00/17202 (2000-03-01), None
patent: 00/17203 (2000-03-01), None
patent: 00/21926 (2000-04-01), None
patent: 00/25780 (2000-05-01), None
patent: 00/26209 (2000-05-01), None
patent: 00/39101 (2000-07-01), None
patent: 00/44750 (2000-08-01), None
patent: 00/49018 (2000-08-01), None
patent: 00/53595 (2000-09-01), None
patent: 00/55161 (2000-09-01), None
patent: 00/59892 (2000-10-01), None
patent: 00/78731 (2000-12-01), None
patent: 01/14375 (2001-03-01), None
patent: 01/29009 (2001-04-01), None
patent: 01/30778 (2001-05-01), None
patent: 01/37835 (2001-05-01), None
patent: 01/47897 (2001-07-01), None
patent: 01/47921 (2001-07-01), None
patent: 01/60816 (2001-08-01), None
patent: 01/64653 (2001-09-01), None
patent: 01/64654 (2001-09-01), None
patent: 01/64655 (2001-09-01), None
patent: 01/64656 (2001-09-01), None
patent: 02/04429 (2002-01-01), None
patent: 02/20512 (2002-03-01), None
patent: 02/066481 (2002-08-01), None
patent: 02/096887 (2002-12-01), None
Traxler, Protein tyrosine kinase inhibitors in cancer treatment, Exp. Opin. Ther. Patents, 7(6): 571-588, 1997.
Bennett, Cecil Textbook of Medicine, 20th Ed., vol. 1, 1997, pp. 1004-1010.
Boschelli et al., Synthesis and Tyrosine Kinase Inhibitory Activity of a Series of 2-Amino-8-H-pyrido[2,3-d]pyrimidines: Identifidation of Potent, Selective Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitors, J. Med. Chem., vol. 41, 1998, pp. 4365-4377.
Donnellan et al., “Cyclin E in human cancers”, FASEB Journal, 13, 1999, pp. 773-780.
Ghosh, “2,4-Bis(Arylamino)-6-Methyl Pyrimidines as Antimicrobial Agents”, J. Indian Chem. Soc., vol. 58, No. 5, 1981, pp. 512-513
El-Kerdawy et al.; “2,4-Bis (Substituted)-5-Nitropyrimidines of Expected Diuretic Action”; Egypt J. Chem. vol. 29, No. 2, 1986, pp. 247-251.
Fiziol Akt Veshchestva, 1975, vol. 7, pp. 68-72.
Ghosh et al.; “2,4-Bis(arylamino)-5-methylpyrimidines as Antimicrobial Agents”; J. Med. Chem., 1967, vol. 10, No. 5, pp. 974-975.
Ghosh, “2,4-Bis(arylamino)-6-methylpyrimidines as an antimicrobial agents”, Chemical Abstract No. 97712f, vol. 95, 1981, pp. 648.
Kornberg, “Focal adhesion kinase and its potential involvement in tumor invasion and metastasis”, Head Neck 20(8): 1998, pp. 745-752.
Griffiths et al., “Androgens, Androgen Receptors, Antiandrogens and the Treatment of Prostate Cancer”, European Urology, vol. 32, No. Suppl. 3, 1997, pp. 24-40, XP001013446.
Woodburn et al., “ZD1839, an epidermal growth factor tyrosine kinase inhibitor selected for clinical development”, Proceedings of the Annual Meeting of the American Assocation for Cancer Research, vol. 38, 1997, p. 633 XP001009911, Abstract.
Deady et al., “Reactions of some quinazoline compounds with ethoxymethyulenemalonic acid derivatives”, J. Heterocycl. Chem., vol. 26, No. 1, 1989, pp. 161-168 XP001000831, examples 14, 16B.
Zimmerman et al., “Phenylamino-Pyrimidine (PAP) Derivatives: A New Class of Potent and Selective Inhibitors of Protein Kinase C (PKC)”, Archiv. der Pharmazie, DE, VCH Verlagsgesellschaft MBH, Weinheim, vol. 329, No. 7, Jul. 1996, pp. 371-376, XP000885618, ISSN: 0365-6233, examples 5-36.
Schmidt et al., “A convenient synthesis of 2-substituted 4-amino-5-pyrimidinecarbonitriles”, J. Heterocycl. Chem., vol. 24, No. 5, 1987, pp. 1305-1307, XP001000522, p. 2, Example 7E.
AstraZeneca AB
Morgan & Lewis & Bockius, LLP
Rao Deepak
LandOfFree
4-Amino-5-cyano-2-anilino-pyrimidine derivatives and their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 4-Amino-5-cyano-2-anilino-pyrimidine derivatives and their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-Amino-5-cyano-2-anilino-pyrimidine derivatives and their... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3474723