4-amino-5-chloro-2-methoxy-n-(6-(1-azabicyclo[3,2,1]octyl)benzam

Details 4-amino-5-chloro-2-methoxy-n-(6-(1-azabicyclo[3,2,1]octyl)benzam 4-amino-5-chloro-2-methoxy-n-(6-(1-azabicyclo[3,2,1]octyl)benzam

1987-06-04

1989-08-15

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D22102

Patent

active

048576476

ABSTRACT:
A compound of formula (XXII): ##STR1## or a compound of formula (XXIII): ##STR2## wherein in formula (XXIII), J.sup.1 -1 is 1 to 4; and Q.sub.6 and Q.sub.7 are on the same carbon atom; and wherein, in formulae (XXII) and (XXIII), Q.sub.6 is NH.sub.2 and Q.sub.7 is H and p is 0 to 2; q is 0 to 3; and one of R.sub.5 and R.sub.6 is hydrogen, C.sub.1-6 alkyl, phenyl or phenyl C.sub.1-3 alkyl, which phenyl moieties may be substituted by C.sub.1-6 alkyl, C.sub.1-6 alkoxy, CF.sub.3 or halogen; and the other of R.sub.5 and R.sub.6 is hydrogen or C.sub.1-6 alkyl.

REFERENCES:
patent: 4182884 (1980-01-01), Wong
patent: 4336259 (1982-06-01), Hadley et al.
A. Chizhoy and M. Rubtsov, "Synthesis of 7-Monosubstitued 1-azabicyclo[3.2.1.]Octanes", Chem. Abstracts, 53, pp. 21958-21959 (1959).
O. Oldenziel, D. van Leusen, and A. van Leusen, "A General One-Step Synthesis of Nitriles from Ketones Using Tosylmethyl Isocyanide, Introduction of a One Carbon Unit", J. Org. Chem., 42, pp. 3114-3118 (1977).
P. Protais, J. Costentin and J. C. Schwartz, "Climbing Behavior Induced by Apomophine in Mice. A Ssimple Test for the Study of Dopamine Receptors in Striatum", Psychopharmacology, 50, pp. 1-6 (1976).

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