4-Amino-4-phenylcyclohexanone ketal compositions and process of

Details 4-Amino-4-phenylcyclohexanone ketal compositions and process of 4-Amino-4-phenylcyclohexanone ketal compositions and process of

1976-06-03

1977-12-27

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

260239A, 260239B, 26029366, 26032687, 2603322R, 2603407, 2603409R, 2603459R, 260465G, 260465R, 2605705CA, 424274, 424275, 424311, 424330, 424560, 424141, 424250, 424251, 424252, A61K 31335, C07D31904, C07D31772

Patent

active

040655733

ABSTRACT:
A class of new 4-amino-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts.
Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.

REFERENCES:
patent: 3901920 (1975-08-01), Lesher et al.

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