4-amino-4-ene-steroids and their use as 5.alpha.-reductase inhib

Details 4-amino-4-ene-steroids and their use as 5.alpha.-reductase inhib 4-amino-4-ene-steroids and their use as 5.alpha.-reductase inhib

1991-07-02

1992-06-09

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

552515, 540 28, C07J 1700, C07J 4100

Patent

active

051208407

ABSTRACT:
The present invention relates to 4-amino-.DELTA..sup.4 -steroids which are useful as inhibitors of 5.alpha.-reductase. The compounds are prepared by the reaction of an appropriate 4-azido steroid with triphenylphosphine in an aqueous inert solvent with heating.

REFERENCES:
patent: 3637668 (1972-01-01), 260
patent: 3780070 (1973-12-01), Shapiro
R. D. Lynch, "Synthesis and Chemistry of Steroidal Azido Ketones. Possible Photoaffinity Labels for Steroids Receptor Proteins," Ph.D. Dissertion (Vanderbilt University), Dec. 1977, pp. xiv, xv, 22,26,40,41,42,95 and 96.
Ekhato et al., J. Chem. Soc. Perkin Trans. I, 1988, 3239.
Chemical Abstracts, 64, 2142e (1966).
Derwent Basic Abstract 9186 (JP 17673/63).
Derwent Basic Abstract 11,765 (JP 4476/64).

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