4-Amino-4-dehydroxy derivatives of efrotomycin and related compo

Details 4-Amino-4-dehydroxy derivatives of efrotomycin and related compo 4-Amino-4-dehydroxy derivatives of efrotomycin and related compo

1983-10-24

1985-05-07

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 168, 536 181, A61K 3171, C07H 306

Patent

active

045157839

ABSTRACT:
Compounds of the efrotomycin class having a 4-hydroxy-2-pyridone terminal group are converted into 4-amino-4-dehydroxy compounds. The amino group may be substituted with various substituents. The processes for the preparation of such compounds are also disclosed. The amino derivatives have antimicrobial, and growth promotion properties and compositions for such uses are also disclosed.

REFERENCES:
patent: 4024251 (1977-05-01), Maiese et al.
Maehr et al., Canadian Journal of Chemistry, 58, p. 501 (1980).
Thien-Schranner et al., Journal of Antibiotics, XXXV, p. 948 (1982).
Wax et al., "Chem. Abst.", vol. 85, 1976, p. 92146(h).

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