4-Amino-4-aryl-cyclohexanones

Details 4-Amino-4-aryl-cyclohexanones 4-Amino-4-aryl-cyclohexanones

1980-10-22

1984-07-17

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Recombinant or stably-transformed bacterium encoding one or...

549 59, 549 74, 549333, 549341, 560 19, 560255, 260239A, 260453A, 260239B, 260464, 424544, 424278, 424267, 424275, 424274, 424298, 424304, 424309, 424311, 546192, 548578, A61K 31335, C07D31772

Patent

active

044606044

ABSTRACT:
A class of 4-amine-4-arylcyclohexanones, their ketals, and acid addition salts have been synthesized and found to be useful for relieving pain in animals. Their analgesic activity appears to be of high order, and in addition some exhibit narcotic antagonist activity that is useful in modifying the cardiovascular, respiratory, and behavioral depression caused by other analgesics. Several show mixed analgesic and narcotic antagonist activity. Preferred compounds of the class are 4-(m-hydroxyphenyl)-4-dimethylaminocyclohexanone ethylene ketal, and 4-(m-hydroxyphenyl)-4-(n-butylmethylamino)cyclohexanone ethylene ketal as free bases and as their hydrochloride salts.
Processes for synthesis and intermediates are described. Unit dosage forms and therapeutic treatments are disclosed.

REFERENCES:
patent: 3097207 (1963-07-01), Maddox et al.
patent: 3145229 (1964-08-01), Godefroi et al.
patent: 3361817 (1968-01-01), L'Italien
patent: 3823189 (1974-07-01), Jirkovsky
patent: 4008269 (1977-02-01), Diamond et al.
patent: 4113866 (1978-09-01), Lednicer
Index Chemicus, 19, 59182 (1965).
Chem. Abstract 88:104776r.
Chem. Abstracts 77:75358w.
Chem. Abstracts 77:114046q.
Chem. Abstracts 85:77727e.

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