4-Amino-3-quinolinecarboxylic acids and esters-antisecretory ant

Details 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory ant 4-Amino-3-quinolinecarboxylic acids and esters-antisecretory ant

1980-03-04

1982-08-10

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546159, 546160, 546161, 546162, A61K 3147

Patent

active

043438040

ABSTRACT:
A method of reducing gastric acidity and treating peptic ulcers and pharmaceutical compositions therefor with certain 4-amino-3-quinolinecarboxylic acids and esters are disclosed. Illustrative of compounds useful in the method which relies on activity as antisecretory activity is the novel compound ethyl 8-methoxy-4-[(2-methylphenyl)amino]-3-quinolinecarboxylate which has the formula: ##STR1##

REFERENCES:
patent: 3470186 (1969-09-01), Hanifin et al.
Hanifin et al., J. Med. Chem., 1969, 12(6) 1096-7.
Sen et al., Chem. Abstr., vol. 52, 13732, (1958).
J. Med. Pharm. Chem., 5 546-58 (1962).
Kermack et al., J. Chem. Soc., 1951, 1389-92.

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