4-amino-3-hydroxy-phthalide, and a process for its preparation

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

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C07D30783

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active

052102319

ABSTRACT:
The present invention relates to 4-amino-3-hydroxy-phthalide, an important intermediate for the synthesis of 3-substituted-5-quinoline-carboxylic acids and to a process for its preparation.

REFERENCES:
patent: 4730056 (1988-03-01), Lowe
Chemical Abstracts, vol. 78, No. 1, Jan. 8, 1973, Columbus, Ohio, U.S.A. Watanabe, Tokuhiro et al. "Indoles, III. New synthesis of 4-indolecarboxylic acid." P. 339, col. 1, para. No. 4 058h & Chem. Pharm. Bull. 1972, 20(10), 2123-7.
Chemical Abstracts, vol. 80, No. 25, Jun. 1974, Columbus, Ohio, U.S.A. Aoki, Katsumichi et al., "Funcigidal compositions containing 4-chlorophthalide derivatives." p. 84, col. 2, para. No. 141 791x & Japan. 73 11,002.
Chemical Abstracts, vol. 90, No. 23, Jun. 4, 1979, Columbus, Ohio, U.S.A. Houbion, J.A. et al. "The synthesis of unamiguously substituted 3-hydroxyphthalides." p. 640, col. 2, para. No. 186 703t & Org. Prep. Proced. Int. 1979, 11(1), 27-32.
Chemical Abstracts, vol. 104, No. 1, Jan. 6, 1986, Columbus, Ohio, U.S.A. Sloan, Kenneth B. et al. "Further reactions of 3-hydroxy-1(3H)-isobenzofuranone with amines." p. 523, col. 1 para. No. 5 724q & J. Heterocycl. Chem. 1985, 22(2), 429-32.

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