4-amino-3-halo-2-pyridinone nucleoside and nucleotide compounds

Details 4-amino-3-halo-2-pyridinone nucleoside and nucleotide compounds 4-amino-3-halo-2-pyridinone nucleoside and nucleotide compounds

1985-07-29

1987-07-21

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514 51, 536 23, 536 29, A61K 3170, C07H 1700

Patent

active

046818731

ABSTRACT:
4-Amino-3-halo-1-.beta.-D-ribofuranosyl-2-(1H)-pyridinone, 4-amino-3-halo-1-(2-deoxy-.beta.-D-pentofuranosyl)-2(1H)-pyridinone, and nucleosides and 4-amino-3-halo-1-(2-deoxy-2,2-difluoro.beta.-D-pentofuranosyl)-2(1H)-pyrid inone nucleosides and nucleotides are useful as antiviral agents and possess in vivo activity against the L1210 murine leukemia cell line.

REFERENCES:
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patent: 3201389 (1965-08-01), Fujimoto et al.
patent: 3317542 (1964-05-01), Haszeldine et al.
patent: 3355278 (1967-10-01), Well et al.
patent: 3853897 (1974-12-01), Witzel et al.
patent: 4526988 (1985-07-01), Hertel
Nesnow et al, J. Het. Chem. 12(5): 941-944, 1975.

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