4-amino-1,5-substituted-1,5-dihydro-imidazol-2-ones

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S398000, C514S401000, C548S311100, C548S326500

Reexamination Certificate

active

07553862

ABSTRACT:
The present invention relates to compounds of formula IwhereinR1, R2,R3, andR4are as defined hereinand to pharmaceutically acceptable acid addition salts thereof. Compounds of formula I or their tautomeric forms are good inhibitors of the glycine transporter 1 (GlyT-1), and have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors. Such compounds are useful for the treatment of schizophrenia.

REFERENCES:
patent: WO 2005/040166 (2005-05-01), None
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Chemical Abstract XP002435251.
Chemical Abstract XP002435252.
Chemical Abstract XP002436293.

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