4.alpha.-substituted avermectin derivatives

Details 4.alpha.-substituted avermectin derivatives 4.alpha.-substituted avermectin derivatives

1992-05-19

1993-11-16

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514450, 536 71, 549264, A61K 3170, A61K 31365

Patent

active

052624005

ABSTRACT:
Avermectin compounds are substituted at the 4a-position: the 4a-methyl group is first derivatized with a hydroxy group which is then substituted with a variety of alkyl, alkoxy alkyl, or polyalkoxy alkyl groups and derivatives thereof. The compounds are potent antiparasitic and anthelmintic agents and compositions for such uses are also disclosed.

REFERENCES:
patent: 3950360 (1976-04-01), Aoki et al.
patent: 4171314 (1979-10-01), Chabala et al.
patent: 4206205 (1980-06-01), Mrozik et al.
patent: 4310519 (1982-01-01), Albers-Schonberg et al.
patent: 4457920 (1984-07-01), Mrozik et al.
Albers-Schonberg, et al (II) J. Am. Soc. 103 pp. 4216-4221 (1981).
Chabala, et al (III) J. Med. Chem. 23 pp. 1134-1136 (1980).
Carter, et al J. Antibiotics 41 pp. 519-529 (1988).
Danishefsky, et al J. Am. Chem. Soc. 111 (1989) pp. 2967-2980.
Hanessien, et al. (I) J. Am. Chem. Soc. 109 (1987) pp. 7063-7067.
Fraser-Reid, et al J. Am. Chem. Soc. 109 (1987) pp. 933-935.
Derwent Abstract, 90-063696/09.

Affiliated with

Also associated with

Rating

4.alpha.-substituted avermectin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4.alpha.-substituted avermectin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4.alpha.-substituted avermectin derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-22617