4-[.alpha.(cyanophenyl)-1-(1,2,3-triazolyl)methyl]-benzonitrile

Details 4-[.alpha.(cyanophenyl)-1-(1,2,3-triazolyl)methyl]-benzonitrile 4-[.alpha.(cyanophenyl)-1-(1,2,3-triazolyl)methyl]-benzonitrile

1994-09-15

1995-10-10

Morris, Patricia L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D24904

Patent

active

054572096

ABSTRACT:
Compounds of formula I ##STR1## wherein Z, R, R.sub.1, R.sub.2 and X are as defined in the description, have valuable pharmaceutical properties and are effective especially against tumours. They are prepared in a manner known per se.

REFERENCES:
patent: 4098894 (1978-07-01), Bushel
patent: 4609666 (1986-09-01), Hirsch et al.
patent: 4657921 (1987-04-01), Frick et al.
patent: 4749713 (1988-06-01), Bowman et al.
patent: 4757076 (1988-07-01), Hirsch et al.
patent: 4762836 (1988-08-01), Hirsch
patent: 4764376 (1988-08-01), Hirsch et al.
patent: 4845222 (1989-07-01), Morr et al.
patent: 4916144 (1990-04-01), Strehlke et al.
patent: 4937250 (1990-06-01), Bowman et al.
patent: 4957934 (1990-09-01), Boyle
patent: 4978672 (1990-12-01), Bowman et al.
patent: 4994478 (1991-02-01), Kishimoto et al.
patent: 5006543 (1991-04-01), Boyle
patent: 5021434 (1991-06-01), Strehlke et al.
patent: 5045558 (1991-09-01), Strehlke et al.
patent: 5071861 (1991-12-01), Bowman et al.
patent: 5073574 (1991-12-01), Lang
patent: 5112845 (1992-05-01), Bowman et al.
patent: 5227393 (1993-07-01), Lang et al.
patent: 5246952 (1993-09-01), Lang
patent: 5352795 (1994-10-01), Bowman et al.
Jones et al "Estrogen Synthetase Inhibitors 2.sup.1 Comparison of the in Vitro Aromatase Inhibitory Activity for a Variety of Nitrogen Heterocycles Substituted with Diarylmethane or Diarylmethanol Groups" J. Med Chem 1990 vol. 33 (416-429).
Taylor et al "Aromatase Inhibition by 5-Substituted Pryimidines and Dihydropyrimidines" J. Med Chem (1987) vol. 30 pp. 1359-1365.
Biagi et al "1,2,3-Triazoles: Structural Changes on two Effective Inhibitors of the Prostaglandin Synthesis in Vitro" Farmaco--Ed. Sc. vol. 43, pp. 597-611 (1988).
Bhatnagar et al "Highly Selective Inhibitor of Estrogen Biosynthesis by CGS 20267, A New Non-Steroidal Aromatase Inhibitor" J. Steroid Biochem Molec. Biol vol. 37 No. 6, pp. 1021-1027 (1990).

Affiliated with

Also associated with

Rating

4-[.alpha.(cyanophenyl)-1-(1,2,3-triazolyl)methyl]-benzonitrile does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-[.alpha.(cyanophenyl)-1-(1,2,3-triazolyl)methyl]-benzonitrile, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-[.alpha.(cyanophenyl)-1-(1,2,3-triazolyl)methyl]-benzonitrile will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2311184