4'Alpha- and 4'beta-amino-4'-desoxyoleandrins, and pharmaceutica

Details 4'Alpha- and 4'beta-amino-4'-desoxyoleandrins, and pharmaceutica 4'Alpha- and 4'beta-amino-4'-desoxyoleandrins, and pharmaceutica

1977-01-13

1978-05-09

Brown, Johnnie R.

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

Conjugate includes potentiator; or composition comprising...

536 5, 536 7, A61K 31705, C07J 1900

Patent

active

040887570

ABSTRACT:
The present invention relates to 4' amino-4' desoxy-oleandrins of the following formula (I) ##STR1## in which R.sup.1 and R.sup.2 may be the same or different and represent hydrogen or a lower alkyl group with 1 to 4 carbon atoms or R.sup.1 and R.sup.2 together with the nitrogen atom form a pyrrolidino, piperidino, or morpholino radical; as well as the physiologically compatible acid addition salts thereof.
These compounds possess positive inotropic cardiac activity and are useful in cases of renal insufficiency.

REFERENCES:
patent: 3898331 (1975-08-01), Petersen
patent: 3914213 (1975-10-01), Stache et al.

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