Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1984-02-22
1986-10-14
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514288, 546 18, 546 66, C07D47116, A61K 31475
Patent
active
046173056
ABSTRACT:
The present invention is concerned with derivatives of 2,3,3a,4,5,6-hexahydro-1H-indolo(3,2,1-de)(1,5)naphthyridine of the formula ##STR1## in the form of base or acid addition salts, preferably with pharmaceutically acceptable acids, wherein one of the groups R1 and R2 represents a lower alkyl group and the other represents a hydrogen atom or R1 and R2 represent each independently an alkyl group or, together an alkanediyl group having from 4 to 6 carbon atoms. R3 represents a lower alkyl group, a hydrogen atom or a benzyl group. And either R5 represents a lower carboalkoxy group or a hydrogen atom and R6 represents with R4 an additional carbon-carbon bond; or R4 represents a hydrogen atom and R6 and R5 represent together an oxygen atom or respectively a hydrogen atom and a hydroxyl group.
REFERENCES:
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patent: 4200638 (1980-04-01), Hannart
patent: 4218453 (1980-08-01), Hannart
Lajos Novak, Janos Rohaly and Csaba Szantay, "Synthesis of Vinca Alkaloids and Related Compounds VI.sup.1 ", Heterocycles, vol. 6, No. 8, 1977, pp. 1149-1157.
J. T. Litchfield, Jr. and F. Wilcoxon, "A Simplified Method of Evaluating Dose-Effect Experiments", The Journal of Pharmacology and Experimental Therapeutics, pp. 99-113.
Le Men et al, Bull. Soc. Chimique de France 1207, 1977.
Daus Donald G.
Omnichem S.A.
Teoli, Jr. William A.
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