4-Alkyldioxyalkylene-5-benzylpyrimidines

Details 4-Alkyldioxyalkylene-5-benzylpyrimidines 4-Alkyldioxyalkylene-5-benzylpyrimidines

1974-03-15

1976-11-16

Rizzo, Nicholas S.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260251R, 260465F, 260473A, 260473R, 424251, C07D23948

Patent

active

039923797

ABSTRACT:
Bactericidal 4'-alkyldioxyalkylene-5-benzylpyrimidines, process for their production, and pharmaceutical compositions or formulations thereof, containing compounds of the general formula: ##SPC1##
Wherein R.sub.1 is an alkyl group containing from 1 to 3 carbon atoms, R is an atom of hydrogen, an atom of halogen, or an alkyl or alkoxy group containing from 1 to 3 carbon atoms, and n is an integer of from 1 to 3,
Exhibit excellent bactericidal activity and low toxicity and are suitable for oral administration.

REFERENCES:
patent: 2909522 (1959-10-01), Hitchings et al.
patent: 3670077 (1972-06-01), Freeman
patent: 3671564 (1972-06-01), Cresswell et al.
patent: 3692787 (1972-09-01), Roth et al.
patent: 3772289 (1973-11-01), Roth et al.
patent: 3819629 (1974-06-01), Roth et al.
patent: 3849407 (1974-11-01), Cresswell et al.
Roth et al., Chem. Abst., vol. 70, col. 96812k, (1969).
Roth et al., J. Med. Pharm. Chem., vol. 5, pp. 1103--1123, (1962).

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