4-alkyl-thiophenyl-ethanolamines, having an activity the cerebra

Details 4-alkyl-thiophenyl-ethanolamines, having an activity the cerebra 4-alkyl-thiophenyl-ethanolamines, having an activity the cerebra

1982-05-27

1986-05-06

Hollrah, Glennon H.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514647, 514653, 544391, 544401, 564307, 564343, 564363, A61K 31495, C07D24104

Patent

active

045872481

ABSTRACT:
4-alkyl-thiophenyl-ethanolamines are disclosed, which are compounds having a therapeutical activity against blood-platelet aggregation, and against lipemia and improving the cerebral circulation, said ethanolamines having the general formula: ##STR1## wherein R and R.sub.1 are alkyl substituents and R.sub.2 is a substituent having an amine character. Due to the presence of two asymmetry centers in their molecule, the compounds concerned can be prepared in the "threo" and the "erythro" configuration: mixtures of the "threo" and the "erythro" forms have also proven effective.

REFERENCES:
patent: 3954417 (1976-05-01), Roba et al.
Cantarelli, et al., "Chemical Abstracts", vol. 98, 1983, col. 98:179414m.

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