((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkeny

Details ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkeny ((4-alkoxypyran-4-yl) substituted) ether, arylalkyl-, arylalkeny

1993-11-12

1995-08-29

Chan, Nicky

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514330, 514255, 5142315, 5142278, 544374, 544149, 544 584, 546207, 549416, 549419, 549420, A61K 3135, C07D30910, C07D40510

Patent

active

054460620

ABSTRACT:
Compounds of the structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.6 and R.sup.7 are hydrogen or alkyl, or R.sup.6 and R.sup.7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## Z is --CH.sub.2 --, oxygen, sulfur, or --NR.sup.9, L.sup.1 and L.sup.2 are selected from a valence bond, alkylene, propenylene, and propynylene; R.sup.1 and R.sup.2 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is selected from oxygen, >NR.sup.10, and ##STR4## L.sup.3 is selected from alkylene of one to three carbon atoms, propenylene, propynylene, ##STR5## and R.sup.3, R.sup.4, and R.sup.5 are hydrogen or alkyl of one to four carbon atoms inhibit the synthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

REFERENCES:
C. Crawley, et al., J. Med. Chem., 1992, 35, 2600-2609.

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