Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1993-05-14
1994-09-13
Higel, Floyd D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514311, 514314, 514460, 5142275, 5142315, 514255, 514274, 5483111, 5483157, 549419, 544 584, 544176, 544315, 544316, 544318, 544388, A61K 3135, A61K 31415, A61K 31495, C07D30910, C07D40510, C07D40512
Patent
active
053469143
ABSTRACT:
Compounds of the structure ##STR1## wherein W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.6 and R.sup.7 are hydrogen or alkyl, or R.sup.6 and R.sup.7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## R.sup.8 is selected from hydrogen, alkyl, haloalkyl, optionally substituted phenyl, hydroxyalkyl, aminoalkyl, carboxyalkyl, (alkoxycarbonyl)alkyl, and (alkylaminocarbonyl)alkyl; Z is --CH.sub.2 --, oxygen, sulfur, or --NR.sup.9 where R.sup.9 is hydrogen or alkyl, L.sup.1 and L.sup.2 are selected from a valence bond, alkylene, propenylene, and propynylene, R.sup.1, R.sup.2, R.sup.3, and R.sup.4 are independently selected from alkyl, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl, Y is selected from oxygen, --NR.sup.10, where R.sup.10 is hydrogen or alkyl, and ##STR4## where n=0, 1, or 2, and R.sup.5 is alkyl, inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.
REFERENCES:
patent: 3671539 (1972-06-01), Saucy
patent: 4897382 (1990-01-01), della Valle et al.
patent: 5155229 (1992-10-01), DiPietro et al.
patent: 5208259 (1993-05-01), Bird et al.
patent: 5276037 (1994-01-01), Dowell et al.
Basha Anwer
Black Lawrence A.
Dellaria Joseph F.
Dorn Linda J.
Lee Wendy
Abbott Laboratories
Higel Floyd D.
Janssen Jerry F.
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