4-alkoxy-2, 6-di-t-butylphenol derivatives

Details 4-alkoxy-2, 6-di-t-butylphenol derivatives 4-alkoxy-2, 6-di-t-butylphenol derivatives

1995-05-18

1997-02-25

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

558271, 560106, 560144, 568442, C07C 69773

Patent

active

056060890

ABSTRACT:
Compounds represented by the general formula (I), as well as intermediates for the synthesis of thereof: ##STR1## where R.sup.1 is a hydrogen atom or an acyl group; R.sup.2 is a lower alkyl group; R.sup.3 is a hydrogen atom or a lower alkyl group; R.sup.4, R.sup.5 and R.sup.6, which may be the same or different, are a hydrogen atom or an optionally substituted alkyl, alkenyl, alkynyl or aryl group; R.sup.2 and R.sup.4, when taken together, may form a 5-membered ring; R.sup.5 and R.sup.6, when taken together, may form a cycloalkyl group or a heterocyclic group in which at least one methylene on the ring of a cycloalkyl group is substituted by an oxygen atom, a sulfur atom or an alkyl-substituted nitrogen atom, provided that R.sup.6 is not present if the ring formed by R.sup.2 and R.sup.4 taken together is a benzofuran ring. The compounds represented by the general formula (I) have a highly selective anti-oxidative activity and are useful as therapeutics of ischemic diseases such as arteriosclerosis and myocardial infarction.

REFERENCES:
Gilbert, J. C. and Pinto, M. (1992), "Development of Novel Phenolic Antioxidants. Synthesis, Structure, Determination, and Analysis of Spiro [2,3-dihydro-5-hydroxy-4,6,7-trimethyl-benzofuran-2,1'-cyclopropane]", The Journal of Organic Chemistry, vol. 57, No. 19, pp. 5271-5276.

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