Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-12-15
2000-10-10
Aulakh, Charanjit S.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
548468, 548465, 548466, 546201, 5462777, 514323, 514339, 514418, A61K 31404, C07D20934
Patent
active
061302392
ABSTRACT:
Disclosed are novel 4-alkenyl- and 4-alkynyl oxindoles having the formula ##STR1## and the pharmaceutically acceptable salts thereof, wherein R.sup.1, R.sup.2, R.sup.3, a, b, and X are as defined herein. These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. These compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer, more particularly, the treatment or control of breast and colon tumors. Also disclosed are pharmaceutical compositions containing the compounds of formula I and II as well as intermediates useful in the preparation of the compounds of formula I and II.
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Sun et al., "Synthesis and Biological Evaluation of Novel 3-[(Substituted pyrrol-2-yl) methylidenyl] indolin-2-ones as Potent and Selective Inhibitors of the Flk-1/KDR Receptor Tyrosine Kinase", Abstract presented at Trip Report: ACS National Meeting, Dallas, Texas, Apr. 1998.
Chen Yi
Corbett Wendy Lea
Dermatakis Apostolos
Liu Jin-Jun
Luk Kin-Chun
Aulakh Charanjit S.
Hoffmann-La Roche Inc.
Johnston George W.
Rocha-Tramaloni Patricia S.
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