4-acyl-2,6-dihalophenyl-phosphoric acid derivatives useful in th

Details 4-acyl-2,6-dihalophenyl-phosphoric acid derivatives useful in th 4-acyl-2,6-dihalophenyl-phosphoric acid derivatives useful in th

1989-09-19

1992-01-14

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

C07F 912

Patent

active

050812742

ABSTRACT:
Phosporic acid derivatives represented by formula (I): ##STR1## wherein X is a halogen and R is --(CH.sub.2).sub.n CH.sub.3 (n=0 to 3), or salts thereof are stable to non-enzymatic hydrolysis and are capable of specifically reacting with acid phosphatase. Therefore, the activity of acid phosphatase in the sample can be determined extremely accurately by reacting said compound with a sample containing acid phosphatase and quantitatively determining the reaction product by colorimetry.

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J. Biol. Chem., 101:93-104 (1933).
J. Vrol. 58:89, (1947).
Canad. Med. Assoc. J. 31: 376, (1934).
J. Clin. Path., 7:322 (1954).
Clin. Chem. Acta., 168: 231 (1987).
Owen et al., Preparation of Aryl and 2,2,2-Trihaloethyl Dihydrogen Phosphates, Synthesis, 1974 (10), 704.705.

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