4,9-Dihydro-4,9-dioxo-1H-cyclohepta[b]pyridine derivatives

Details 4,9-Dihydro-4,9-dioxo-1H-cyclohepta[b]pyridine derivatives 4,9-Dihydro-4,9-dioxo-1H-cyclohepta[b]pyridine derivatives

1981-08-21

1983-04-26

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546183, 560125, C07D22104, A61K 31435

Patent

active

043813046

ABSTRACT:
Aldose reductase inhibitors of the formula ##STR1## in which R.sup.1 is COOH and R.sup.2 is hydrogen, 8-halo or 6-hydroxy, or R.sup.1 is CON(R.sup.3)-CH.sub.2 COOH wherein R.sup.3 is lower alkyl and R.sup.2 is hydrogen or 8-halo are useful for treating diabetic complications.

REFERENCES:
Hayman, J. Biol. Chem., 240,877 (1965).

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