Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1977-03-24
1978-01-24
Jiles, Henry R.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
2602949, 260295Q, 260295R, C07D47104
Patent
active
040703606
ABSTRACT:
A new heterocycle, 5,11-diazatetracyclo-[6.2.2.0.sup.2,7.0.sup.4,9 ]dodecane, is prepared by heating an endo-diazatricyclo[6.2.2.0.sup.2,7 ]dodec-11-ene substituted in the 7 and 11 positions with electron withdrawing groups. 2,9-Bis-phenylacetyl derivatives of the new heterocycle and closely related derivatives are potent analgesic agents.
REFERENCES:
liberatore, F. et al., Tett. Lett. #26, 2381-2384 (1971).
Fisher Michael H.
Flataker Lars M.
Grabowski Edward J. J.
Patchett Arthur A.
ten Broeke Jan
Jiles Henry R.
Merck & Co. , Inc.
Monaco Mario A.
Nicholson William H.
Schwartz Richard A.
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