4,7-Dihydro-4,7-dioxi-1H-cyclohepta[b]pyridine derivatives

Details 4,7-Dihydro-4,7-dioxi-1H-cyclohepta[b]pyridine derivatives 4,7-Dihydro-4,7-dioxi-1H-cyclohepta[b]pyridine derivatives

1981-08-21

1983-05-03

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

546183, 560125, C07D22104, A61K 31435

Patent

active

043820883

ABSTRACT:
Aldose reductase inhibitors of the formula ##STR1## in which R.sup.1 is CH.sub.2 COOR.sup.4 wherein R.sup.4 is hydrogen or lower alkyl; R.sup.2 is COOR.sup.5 wherein R.sup.5 is hydrogen or lower alkyl; and R.sup.3 is lower alkoxy, benzyloxy or CH.sub.2 COOR.sup.6 wherein R.sup.6 is hydrogen or lower alkyl; with the provisos that when R.sup.4 is hydrogen then R.sup.5 and R.sup.6 is hydrogen; and that when R.sup.4 is lower alkyl then R.sup.5 and R.sup.6 are lower alkyl with R.sup.4 and R.sup.6 being the same lower alkyl; are useful for treating diabetic complications.

REFERENCES:
patent: 3821383 (1974-06-01), Sestanj et al.
patent: 4130649 (1978-12-01), Bagli
Hayman, J. Biol. Chem. 240, 877 (1965).
D. Dvornik et al., Science, 182, 1146 (1973).
M. J. Peterson et al., Metabolism, 28, (Suppl. 1), 456 (1979).
R. Slack and C. F. Attridge, Chemistry and Industry, 471 (1952).
K. Yamane, Chem. Abstr., 56, 4486 (1962) for Nippon Kagaku Zasshi, 81, 295 (1960).

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