Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1999-03-23
2000-08-01
Krass, Frederick
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 6, 435 91, 435968, 436 86, 436 94, 436 96, 436 98, 436161, 436162, 436800, 536 231, 536 243, 536 2532, 536 254, 536 256, 935 77, A01N 4304
Patent
active
060967234
ABSTRACT:
Long wavelength, narrow emission bandwidth fluorecein dyes are provided for detecting spacially overlapping target substances. The dyes comprise 4,7-dichlorofluoresceins, and particularly 2',4',5', 7'-tetrachloro-4,7-dichloro-5- (and 6-) carboxyfluoresceins. Methods and kits for using the dyes in DNA analysis are provided.
REFERENCES:
patent: 4318846 (1982-03-01), Khanna et al.
patent: 4439356 (1984-03-01), Khanna et al.
patent: 4481136 (1984-11-01), Khanna et al.
patent: 4647578 (1987-03-01), Crounse et al.
patent: 4855225 (1989-08-01), Fung et al.
patent: 4933471 (1990-06-01), Lee
patent: 4997928 (1991-03-01), Hobbs, Jr.
patent: 5066580 (1991-11-01), Lee
patent: 5171534 (1992-12-01), Smith et al.
patent: 5188934 (1993-02-01), Menchen et al.
patent: 5654442 (1997-08-01), Menchen et al.
patent: 5885778 (1999-03-01), Menchen et al.
Connel et al., "Automated DNA Sequence Analysis," BioTechniques, 5(4): 342-348 (1987).
Karger et al., "Multiwavelength Fluorescence Detection for DNA Sequencing Using Capillary Electrophoresis," Nucleic Acids Research, 19(18): 4955-4962 (1991).
Wehry, chapter 3 in Guilbault, editor, Practical Fluorescence, 2nd. Ed., (Marcel Dekker, New York, 1990).
Wehry, chapter 4 in Guilbault, editor, Practical Fluorescence, 2nd. Ed., (Marcel Dekker, New York, 1990).
Haugland, chapter 2 in Steiner, editor, Excited States of Biopolymers (Plenum Press, New York, 1983).
Lee et al., "Vita Blue: A New 644-nm Excitable Fluorescent Dye for Cell Analysis," Cytometry, 10:151-164 (1989).
Pringle, et al., "Automated Nucleotide Sequence Analysis Accuracy Is Strongly Dependent Upon Optimal Template Levels and Avoidance of Gel Overload," DNA Core Facilities Newsletter, 1:15-21 (1988).
Kaambara, et al., "Optimization of Parameters in a DNA Sequenator Using Fluorescence Detection," Biotechnology, 6:816-821 (1988).
Smith, et al., "Fluorescence Detection in Automated DNA Sequence Analysis," Nature, 321:674-679 (1986).
Prober, et al., "A System for Rapid DNA Sequencing with Fluorescent Chain-Terminating Dideoxynucleotides," Science, 238:336-341 (1987).
Kirkbright, G.F., "Chapter 9. Fluorescent Indicators," from Indicators (Bishop, E., ed., Pergamon Press, Oxford et al., pp. 685-698), 1987.
Marshall, P.N., "Rules for the Visible Absorption Spectra of Halogenated Fluorescein Dyes," Histochemical Journal, 7:299-303 (1975).
Smith et al, "The Synthesis and Use of Fluorescent Oligonucleotides in DNA Sequence Analysis", Methods in Enzymology, 155: 260-301 (1987).
Chakerian Vergine
Connell Charles R.
Fung Steven
Hershey N. Davis
Lee Linda G.
Krass Frederick
Macevicz Stephan C.
Powers Vincent M.
The Perkin-Elmer Corporation
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