Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving virus or bacteriophage
Patent
1996-09-25
1998-02-17
Marschel, Ardin H.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving virus or bacteriophage
435201, 536 111, 536 172, 536 186, 536 187, C12Q 170, C12N 926, C07H 100, C07H 1500
Patent
active
057190208
ABSTRACT:
Chromogenic and fluorogenic 4,7-dialkoxy-N-acetylneuraminic acid substrates of the general formula ##STR1## are provided wherein R.sub.1 and R.sub.2 are alkyl groups containing 1 to 4 carbon atoms and R.sub.3 is a chromogenic or fluorogenic group. These substrates can be used to detect influenza types A and B in clinical samples or specimens. More particularly, these 4,7-dialkoxy-N-acetylneuraminic acid substrates can be used to distinguish between various viruses having neuraminidase reactivity. Thus, influenza type A and B viruses can be distinguished from parainfluenza type 1, 2, 3, and 4, and mumps using the 4,7-dialkoxy-N-acetylneuraminic acid derivatives of this invention. Diagnostic methods employing these substrates are provided to identify influenza type A and B viruses in clinical specimens and to distinguish from other viruses having neuraminidase reactivity.
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Hansjergen Joyce Anne
Liav Avraham
Shimasaki Craig David
Marschel Ardin H.
Oklahoma Medical Research Foundation
Riley Jezia
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