4,7-benzofurandione derivatives useful as inhibitors of leukotri

Details 4,7-benzofurandione derivatives useful as inhibitors of leukotri 4,7-benzofurandione derivatives useful as inhibitors of leukotri

1987-06-18

1988-10-18

Schwartz, Richard A.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514422, 514452, 514456, 514464, 514469, 514470, 546196, 548525, 549362, 549398, 549435, 549466, 549467, 549468, 549469, 549470, A61K 3134, C07D30786

Patent

active

047788054

ABSTRACT:
4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention. ##STR1##

REFERENCES:
patent: 4663347 (1987-05-01), Atkinson et al.
Chem. Abstracts, 142937q, vol. 85 (1976).

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