Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-07-11
1990-11-06
Bleutge, John C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D30778
Patent
active
049688219
ABSTRACT:
4,7-Benzofurandione derivatives of Formula I, pharmaceutical compositions, and methods of treatment are disclosed. These compounds are useful as inhibitors of mammalian leukotriene biosynthesis. As such, these compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular disorders, inflammation, psoriasis and allergic conjunctivitis. The compounds are also useful as analgesics and as cytoprotective agents. Also disclosed are novel intermediates useful for the preparation of the 4,7-benzofurandiones of this invention. ##STR1##
REFERENCES:
patent: 4663347 (1987-05-01), Atkinson et al.
patent: 4778805 (1988-10-01), Adams et al.
Morrison et al., "Organic Chemistry", Allyn and Bacon, Inc., Boston, Fifth Edition, 1987, p. 1092.
Adams Julian
Belanger Patrice C.
Belley Michel L.
Guindon Yvan
Rokach Joshua
Bleutge John C.
Jagannathan Vasu S.
Lopez Gabriel
Merck Frosst Canada Inc.
Pfeiffer Hesna J.
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