4-,6- or 7-hydroxyindoles with N-oxide groups and the use...

Details 4-,6- or 7-hydroxyindoles with N-oxide groups and the use... 4-,6- or 7-hydroxyindoles with N-oxide groups and the use...

2006-06-27

2006-06-27

Morris, Patricia L. (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S278100

Reexamination Certificate

active

07067536

ABSTRACT:
The invention relates to substituted 4-, 6- or 7-hydroxyindoles with N-oxide groups, process for their preparation, pharmaceutical preparations which comprise these compounds, and the pharmaceutical use of these compounds, which are inhibitors of phosphodiesterase 4, as active ingredients for the treatment of disorders which can be influenced by inhibition of phosphodiesterase 4 activity in particular in immunocompetent cells (e.g. macrophages and lymphocytes) by the compounds of the invention.

REFERENCES:
patent: 6232327 (2001-05-01), Nickel et al.
patent: 6251923 (2001-06-01), Hofgen et al.
patent: 6432987 (2002-08-01), Gunther et al.
patent: 2002/0111351 (2002-08-01), Hofgen et al.
patent: 2002/0115651 (2002-08-01), Hofgen et al.
patent: 2002/0119971 (2002-08-01), Hofgen et al.
patent: 2002/0137745 (2002-09-01), Hofgen et al.
patent: 2003/0134876 (2003-07-01), Hofgen et al.
patent: 2003/0153759 (2003-08-01), Koya et al.
patent: 2003/0195360 (2003-10-01), Nickel et al.
patent: 2003/0204090 (2003-10-01), Chimmanamada, et al.
patent: 2004/0116462 (2004-06-01), Ono et al.
patent: 2004/0147759 (2004-07-01), Hofgen et al.
patent: 2004/0266760 (2004-12-01), Hofgen et al.
patent: 196 36 150 (1998-03-01), None
patent: 198 14 838 (1999-10-01), None
patent: WO-99/55696 (1999-11-01), None
Orally Active Indole N-oxide . . . inhibitors, Hulme, et al. Bioorganic & Medicinal Chem. Letters. (1998).
Anti-Inflammatory and Immunomodulatory . . . In Vitro, Hatzelmann, et al. Journ. Of Pharmacology and Experimental Therapeutics. Vo.. 297. (2001).

Affiliated with

Also associated with

Rating

4-,6- or 7-hydroxyindoles with N-oxide groups and the use... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 4-,6- or 7-hydroxyindoles with N-oxide groups and the use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 4-,6- or 7-hydroxyindoles with N-oxide groups and the use... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3685569