4,6-dichloropyrimidine and related compounds

Details 4,6-dichloropyrimidine and related compounds 4,6-dichloropyrimidine and related compounds

1995-04-25

1996-12-10

Gupta, Yogendra N.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544330, C07D23948

Patent

active

055832261

ABSTRACT:
A novel pyrimidine derivative, N-(2-amino-4,6-dichloropyrimidine-5-yl)formamide for use, e.g., in the production of antiviral nucleotide derivatives, can be made by a process involving cyclyzing an aminomalonic ester with guanidine or its salt in the presence of a base to produce 2,5-diamino-4,6-dihydroxypyrimidine or its salt, chlorinating this product with a chlorinating agent in the presence of an amide to produce 4,6-dichloropyrimidine, and reacting the 4,6-dichlororpyrimidine with an aqueous solution of a carboxylic acid to produce the N-(2-amino-4,6-dichloropyrimidine-5-yl)formammide. Novel also are 4,6-dichloropyrimidine, 4,6-dichloro-N'-(dimethylaminomethylene)pyrimidine-2,5-diamine, 4,6-dichloro-N'-(piperidine-1-ylmethylene)pyrimidine-2,5-diamine, and a process for making 2,5-diamino-4,6-dichloropyrimidine.

REFERENCES:
patent: 5294710 (1994-03-01), Stucky et al.
M. Legraverend et al., "A New Route to 2,5-Diamino-4,6-dichloropyrimidine . . .", Synthesis, vol. 7 (1990), pp. 587-589.

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