4,5 Dihydroimidazole compounds which have useful pharmaceutical

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548336, 514397, 546211, C07D40112, A61K 3141

Patent

active

049180835

ABSTRACT:
A compound of formula (I): ##STR1## or a pharmaceutically acceptable salt, ester or amide thereof, or a pharmaceutically acceptable solvate thereof, wherein:
Z represents a residue of a substituted or unsubstituted aryl group,
A.sup.1 represents a substituted or unsubstituted methylene group or a substituted or unsubstituted ethylene group;
A.sup.2 represents a substituted or unsubstituted methylene group or a substituted or unsubstituted ethylene group;
providing that at least one of A.sup.1 or A.sup.2 represents a substituted methylene group or a substituted ethylene group,
X represents O or NR.sup.o wherein R.sup.o represents a hydrogen atom, a substituted or unsubstituted alkyl group, a substituted or unsubstituted aryl group, an alkanoyl group substituted or unsubstituted in the alkyl moiety, or an arylalkyl moiety substituted or unsubstituted in the aryl moiety,
p represents an integer 2 or 3, and
q represents an integer in the range of from 1 to 12;
a process for preparing such a compound, a composition comprising such a compound and the use of such a compound in medicine.

REFERENCES:
patent: 4217357 (1980-08-01), Cross et al.
patent: 4511573 (1985-04-01), Renfroe

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