4,5-Dihydroimidazo-[1,2-a]quinoxaline-2-carboxylic acids and the

Details 4,5-Dihydroimidazo-[1,2-a]quinoxaline-2-carboxylic acids and the 4,5-Dihydroimidazo-[1,2-a]quinoxaline-2-carboxylic acids and the

1983-04-22

1984-08-07

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424246, 4242484, 544 60, 544120, 544346, 544225, 2602433, A61K 31495, C07D48704

Patent

active

044643730

ABSTRACT:
Novel imidazoquinoxalines of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydroxy, alkoxy of 1 to 5 carbon atoms and cyclohexylcarbonyloxymethoxy, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkoxycarbonylvinyl of 4 to 7 carbon atoms, --COR, --CONH(CH.sub.2).sub.n --X and --A--(CH.sub.2).sub.m --Y, R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, cycloalkyl of 3 to 10 carbon atoms, alkenyl of 2 to 4 carbon atoms, alkoxy of 1 to 5 carbon atoms, alkoxycarbonyl of 2 to 5 carbon atoms, amino, --CF.sub.3, --CHCl.sub.2 --, phenyl, aralkyl of 7 to 10 carbon atoms, aralkoxy of 7 to 10 carbon atoms, n is 0 and X is phenyl or n is an integer from 1 to 5 and X is selected from the group consisting of ##STR2## R.sub.3 and R.sub.4 are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, aryl of 6 carbon atoms and aralkyl of 7 to 8 carbon atoms or R.sub.3 and R.sub.4 taken together with the nitrogen atom to which they are attached form a saturated heterocycle with 4 to 8 ring carbon atoms optionally containing at least one oxygen atom or sulfur atom or nitrogen atom optionally substituted with alkyl of 1 to 3 carbon atoms or alkoxycarbonyl of 2 to 5 carbon atoms, Hal is chlorine or bromine, A is selected from the group consisting of ##STR3## m is a integer from 1 to 3, Y is ##STR4## their non-toxic, pharmaceutically acceptable acid addition salts when R.sub.1 is other than --OH and their salts with pharmaceutically acceptable metals or nitrogen bases when R.sub.1 is --OH, having antiallergic properties.

REFERENCES:
patent: 4254123 (1981-03-01), Ramm et al.
patent: 4333934 (1982-06-01), Bames et al.

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