4,5-dihydro-oxazol-2-yl amine derivatives

Details 4,5-dihydro-oxazol-2-yl amine derivatives 4,5-dihydro-oxazol-2-yl amine derivatives

2011-08-02

2011-08-02

Saeed, Kamal (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S256000, C514S340000, C514S374000, C544S105000, C544S333000, C546S271400, C548S233000

Reexamination Certificate

active

07989449

ABSTRACT:
The present invention relates to a compounds of formula Iwherein R1, R1′, R2, R3, R4, X, Ar, and m are as defined in the specification and claims and pharmaceutically active acid addition salts thereof. Compounds of the invention have Asp2 (β-secretase, BACE 1 or Memapsin-2) inhibitory activity and are useful for the treatment of diseases characterized by elevated β-amyloid levels or β-amyloid deposits, particularly Alzheimer's disease.

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