4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol and salts, their prepa

Details 4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol and salts, their prepa 4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol and salts, their prepa

1979-08-30

1981-11-03

Sutto, Anton H.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544238, A61K 3150, C07D23722

Patent

active

042986095

ABSTRACT:
4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol or pharmaceutically-acceptable acid-addition salt thereof is useful as a blood pressure lowering agent. 4,5-Dihydro-6-(4-pyridinyl)-3-pyridazinol is prepared by reacting .gamma.-oxo-.gamma.-(4-pyridinyl)butyronitrile with a hydrazine salt of a strong inorganic or organic sulfonic acid. Said 4,5-dihydro-6-(4-pyridinyl)-3-pyridazinol or pharmaceutically-acceptable salt thereof is shown as the active ingredient in pharmaceutical compositions for lowering blood pressure and in the method for lowering blood pressure in a patient having elevated blood pressure.

REFERENCES:
McEvoy et al. J. Org. Chem. 38, 4044-4048 (1978).
McEvoy et al. J. Med. Chem. 17, 281-286, (1974).
Curran et al. J. Medicinal Chemistry 17, 273-281, (1974).

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