4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)- py

Details 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)- py 4,5-dihydro-6-[2-[4-(1H-imidazol-1-yl)phenyl]-ethenyl]-3(2H)- py

1984-11-09

1986-07-08

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544238, 544239, C07D40310, A61K 3150

Patent

active

045993327

ABSTRACT:
4,5-Dihydro-6-[2-[4-(1H -imidazol-1-yl)phenyl]alkylenyl or alkylene-3(2H)-pyridazinones and related compounds and pharmaceutically acceptable acid addition salts thereof are useful as cardiotonic and antihypertensive agents.
The above compounds cause a significant increase in myocardial contractility in the dog and also cause a decrease in blood pressure in the spontaneously hypertensive rat. The compounds are produced by reacting the appropriate .gamma.-oxobutanoic acid with a suitably substituted hydrazine to provide 4,5-dihydro-6-[4-[imidazolylphenyl]-alkenylene or alkylene-3(2H)-pyridazinones which may be oxidized to 6-[4-[imidazolylphenyl]alkenylene or alkylene-3(2H)-pyridazinones.

REFERENCES:
patent: 4353905 (1982-10-01), Sircar
patent: 4507298 (1985-03-01), Lautenschlager

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