4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acid de

Details 4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acid de 4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acid de

1977-08-19

1978-08-08

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544250, A61K 31505, C07D48714

Patent

active

041057660

ABSTRACT:
4,5-Dihydro-5-oxopyrazolo[1,5-a]quinazoline-3-carboxylic acids and esters and alkali metal salts thereof, useful as anti-inflammatory, anti-allergic and anti-parasitic agents, are prepared by reacting a 4- or 5-R.sub.3 -2-carboxyphenylhydrazine with a lower-alkyl ethoxymethylenecyanoacetate and, if desired, saponifying the ester group and if desired, N-alkylating the product by reaction with an R.sub.2 -halide in the presence of an acid-acceptor.

REFERENCES:
patent: 2861076 (1958-11-01), Knott et al.
patent: 3313815 (1967-04-01), Wolfe et al.
patent: 3594379 (1971-07-01), Hardtmann
patent: 3862191 (1975-07-01), El-Haj et al.
Wright, "J. Heterocyclic Chem.", vol. 6, 1969, pp. 947-948.

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