4,5-dihydro-4-oxo-pyrrolo[1,2-a]quinoxalinones and corresponding

Details 4,5-dihydro-4-oxo-pyrrolo[1,2-a]quinoxalinones and corresponding 4,5-dihydro-4-oxo-pyrrolo[1,2-a]quinoxalinones and corresponding

1993-08-24

1995-04-11

Shah, Mukund J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

544115, 544344, 544346, A61K 31505, A61K 31535, C07D47114, C07D48714

Patent

active

054058473

ABSTRACT:
Novel compounds of the formula ##STR1## where the phenyl ring can also contain a nitrogen atom instead of a CH group, R.sub.1 is C.sub.2 -C.sub.6 -alkenyl, C.sub.2 -C.sub.6 -alkynyl, hydroxy, C.sub.1 -C.sub.6 -alkoxy, C.sub.3 -C.sub.6 -alkenyloxy, C.sub.3 -C.sub.6 -alkynyloxy, C.sub.2 -C.sub.6 -alkanoyloxy, benzoyloxy, morpholinocarbonyloxy, C.sub.1 -C.sub.6 -alkyloxycarbonyloxy, C.sub.1 -C.sub.6 -alkylaminocarbonyloxy, C.sub.1 -C.sub.6 -dialkylaminocarbonyloxy or the group -Alk-A, where Alk represents C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -hydroxyalkyl or C.sub.3 -C.sub.6 -cycloalkyl and the symbol A represents hydrogen or other substituents.
R.sub.2, R.sub.3 and R.sub.4 represent various substituents, where R.sub.1 may also be hydrogen, when R.sub.2 is the group ##STR2## and R.sub.5 represents phenyl, C.sub.1 -C.sub.4 -alkoxyphenyl or diphenylmethyl and R.sub.3 and R.sub.4 are hydrogen and their salts. The compounds provide anti-allergic, anti-asthmatic, anxiolytic and hypotensive effects.

REFERENCES:
patent: 4151280 (1979-04-01), Rowlands et al.
patent: 4446323 (1984-05-01), Freed et al.
Davey et al. (J. Med. Chem. (1991), 34 2671-2677).
Ager, (J. Med. Chem (1988), 31 1098-1115).
Adegoke (J. Heterocycl. Chem. 19 (1982) 1169-72).
Nagarajan et al., Indian Journal of Chemistry, 1972, 10(4):344-350.

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