4,5-Dihydro-2-lower alkoxycarbonylamino-4-phenylimidazoles and s

Details 4,5-Dihydro-2-lower alkoxycarbonylamino-4-phenylimidazoles and s 4,5-Dihydro-2-lower alkoxycarbonylamino-4-phenylimidazoles and s

1977-10-17

1978-12-12

Trousof, Natalie

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

548315, 548316, A61K 31415, C07D23348

Patent

active

041296613

ABSTRACT:
4,5-Dihydro-2-lower alkoxycarbonylamino-4-phenylimidazole, and substituted phenyl derivatives thereof, and pharmaceutically acceptable salts thereof, and methods of preparing such compounds. In one method, the compounds can be prepared by treating the corresponding .beta.-amino-.beta.-(phenyl or substituted phenyl)-ethylamine with the desired 1,3-bis(alkoxycarbonyl)-S-methylisothiourea or 1-alkoxycarbonyl-S-methylisothiourea. The compounds can also be prepared by treating the corresponding 2-amino-4,5-dihydro-4-(phenyl or substituted phenyl)-imidazole with the desired dialkylcarbonate. The subject compounds are useful as psychotherapeutic agents for treating, preventing or palliating abnormal conditions, in mammals, which are related to the central nervous system.

REFERENCES:
atkins et al., J. Chem. Soc. (London) Perkin Trans. I 1973(22) pp. 2644-2646.
Matier et al., J. Med. Chem. 1973, vol. 16, pp. 901-908.
Mengelberg, Chem. Abst., 1959, vol. 53, col. 2210.

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