4,5-Deoxymaytansinoids, their use and pharmaceutical composition

Details 4,5-Deoxymaytansinoids, their use and pharmaceutical composition 4,5-Deoxymaytansinoids, their use and pharmaceutical composition

1981-09-29

1983-02-01

Bond, Robert T.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424851, 2602393T, 2602393P, C07D49816, A61K 31535

Patent

active

043715338

ABSTRACT:
This invention relates to 4,5-deoxymaytansinoid compounds represented by the formula ##STR1## wherein X is a hydrogen atom or an alkyl or acyl group, Y is a hydrogen or chlorine atom, and R is a hydrogen atom or a carboxylic acid-derived acyl group, and methods of producing the same. The compounds are useful as antitumor, antiprotozoal and antifungal agents.

REFERENCES:
patent: 4162940 (1979-07-01), Higashide et al.
Corey et al., "J. Am. Chem. Soc." vol. 102 (1980) pp. 6613-6615 (Oct. 8, 1980).
S. M. Kupchan, Journal of Medicinal Chemistry, 21(1), 31-37. (1978).
E. J. Corey et al., J. Am. Chem. Soc., 100(9), 2916 (1978).
E. J. Corey et al., J. Am. Chem. Soc., 102(4), 1439 (1980).

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