4,5-Bis(aryl)-4H-1,2,4-triazole derivatives and analgesic use

Details 4,5-Bis(aryl)-4H-1,2,4-triazole derivatives and analgesic use 4,5-Bis(aryl)-4H-1,2,4-triazole derivatives and analgesic use

1983-11-17

1985-04-23

Rollins, Alton D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

260544D, 260544N, 548262, 564 74, 564148, 564149, 564150, 564151, 564226, 549436, A61K 31395, C07D24908

Patent

active

045129975

ABSTRACT:
Novel 4H-1,2,4-triazoles of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 may be in different positions of the benzene rings and are individually selected from the group consisting of hydrogen, --OH, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, --CF.sub.3, --NO.sub.2, --NH.sub.2 and --NH--AlK and ##STR2## and AlK, AlK.sub.1 and AlK.sub.2 are alkyl of 1 to 4 carbon atoms or R.sub.1 and R.sub.2 together and/or R.sub.3 and R.sub.4 together are methylenedioxy, R is selected from the group consisting hydrogen, alkyl of 1 to 4 carbon atoms, --CH.sub.2 --COOH and --CH.sub.2 --COOAlK.sub.3 and AlK.sub.3 is alkyl of 1 to 4 carbon atoms and their non-toxic, pharmaceutically acceptable acid addition salts having a remarkable analgesic activity and a novel method for their preparation.

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Beilstein's Handbuch der Organischen Chemie, vol. 26, Zweites Erganzungswerk (Vierte Auflag, Berlin, 1954), p. 35.

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