Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1999-12-15
2000-11-28
Stockton, Laura L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514322, 514366, 514375, 514387, 514388, 546199, 548151, 548218, 5483021, A61K 314188, A61K 31424, A61K 31429, C07D48704
Patent
active
061536342
ABSTRACT:
Disclosed are novel 4,5-azolo-oxindoles having the formula ##STR1## These compounds inhibit cyclin-dependent kinases (CDKs), in particular CDK2. Thus, these compounds and their pharmaceutically acceptable salts, and prodrugs of said compounds, are anti-proliferative agents useful in the treatment or control of cell proliferative disorders, in particular cancer. Also disclosed are pharmaceutical compositions containing these compounds, and methods for the treatment and/or prevention of cancer, particularly in the treatment or control of solid tumors using these compounds, as well as intermediates useful in the preparation of compounds of formula I.
REFERENCES:
patent: 4556672 (1985-12-01), Kadin
patent: 4730003 (1988-03-01), Von Der Saal et al.
patent: 5206261 (1993-04-01), Kawaguchi et al.
patent: 5322950 (1994-06-01), Sircar et al.
patent: 5374652 (1994-12-01), Buzzetti et al.
patent: 5397787 (1995-03-01), Buzzetti et al.
patent: 5409949 (1995-04-01), Buzzetti et al.
patent: 5488057 (1996-01-01), Buzzetti et al.
patent: 5576330 (1996-11-01), Buzzetti et al.
patent: 5792783 (1998-08-01), Tang et al.
patent: 5834504 (1998-11-01), Tang et al.
patent: 5883113 (1999-03-01), Tang et al.
patent: 5883116 (1999-03-01), Tang et al.
patent: 5886020 (1999-03-01), Tang et al.
Abstract Acc. No. 94-028085/199404 (Abstract of EP 0580502), 1994.
Sun et al., J. Med. Chem., 41:2588-2603 (1998).
Sun et al., "Synthesis and Biological Evaluation of Novel 3-[(Substituted pyrrol-2-yl)methylidenyl]indolin-2-ones as Potent and Selective Inhibitors of the Flk-1/KDR Receptor Tyrosine Kinase", Abstract presented at Trip Report: ACS National Meeting, Dallas, Texas, (Apr. 1998).
Luk Kin-Chun
Michoud Christophe
Mischke Steven Gregory
Hoffmann-La Roche Inc.
Johnston George W.
Rocha-Tramaloni Patricia S.
Stockton Laura L.
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