Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1979-11-05
1984-02-21
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
548517, A61K43138, C07D40904
Patent
active
044329920
ABSTRACT:
Novel 4-[5(and 4)-substituted-2-thienyl]-3-hydroxy-3-pyrroline-2,5-diones are disclosed which inhibit glycolic acid oxidase and thus are useful in the treatment and prevention of calcium oxalate kidney stone formation. A novel process for their preparation is also disclosed.
REFERENCES:
patent: 3340263 (1967-09-01), Stachelln et al.
Liao et al., Arch. Biochem. Biophys., 154, (1973) pp. 68-75.
Haulay J. Pharm. Chim, 24, 1936, pp. 537.548.
G. S. Skinner et al., J. Am. Chem. Soc., 73, (1951) pp. 2230-2233; 70 (1948) pp. 4011-4013.
Randall et al., J. Med. Chem., 22, (1979) pp. 608-614.
Cragoe, Jr. Edward J.
Rooney Clarence S.
Williams Haydn W. R.
Coughlan, Jr. Paul M.
Merck & Co. , Inc.
Speer Raymond M.
Sringer D. B.
Sudol, Jr. Michael C.
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