4,5.alpha.Epoxymorphinan -6-spiro-2'-(4'-carboxy,1',3'-thiazolid

Details 4,5.alpha.Epoxymorphinan -6-spiro-2'-(4'-carboxy,1',3'-thiazolid 4,5.alpha.Epoxymorphinan -6-spiro-2'-(4'-carboxy,1',3'-thiazolid

1983-03-21

1985-01-29

Daus, Donald G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546 15, 544125, 514231, C07D48908, A61K 31485

Patent

active

044965702

ABSTRACT:
Compounds the structural formula ##STR1## or their pharmaceutically acceptable salts, wherein X is H or CH.sub.3, Z is NH.sub.2 or OR.sub.6, R.sub.1 is a C.sub.1-8 alkyl, C.sub.3-6 -cycloalkylmethyl, or phenyl-C.sub.1-2 alkyl group,

REFERENCES:
patent: 2619485 (1952-11-01), Chabrier et al.
patent: 4362870 (1982-12-01), Portoghese
Hazum et al., Biochemical and Biophysical Research Communications, vol. 104, pp. 347-353, (01/15/82).
British Drug Houses, Ltd., Chemical Abstracts, vol. 61, 4365e-4366d, (1964).

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