4,5.alpha.-Epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-ox

Details 4,5.alpha.-Epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-ox 4,5.alpha.-Epoxy-3-hydroxy or methoxy-7-(1-hydroxy-alkyl or 1-ox

1980-12-10

1982-08-31

Sutto, Anton H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

424260, C07D48902, A61K 31485

Patent

active

043473610

ABSTRACT:
Disclosed are 4,5.alpha.-epoxy-3-hydroxy or methoxy-7-(1-hydroxyalkyl or 1-oxoalkyl)morphinan-6-one compounds characterized by the structural formulae: ##STR1## In the foregoing formulae R is methyl, cyclopropylmethyl, cyclobutylmethyl, propargyl, allyl, dimethylallyl, cis-chloroallyl or furfuryl; R.sub.1 is H or methyl; R.sub.2 is straight or branched chain alkyl of from 1 to 10 carbon atoms, aryl, substituted aryl or arylalkyl, in which the alkyl group contains from 1 to 6 carbon atoms, and R.sub.3 is a straight chain alkyl of 1 to 4 carbon atoms.

REFERENCES:
patent: 3433791 (1969-03-01), Bentley
patent: 3488354 (1970-01-01), Brown et al.
Kotick et al., J. Med. Chem., vol. 23, No. 2, pp. 166-174 (02/80).
Stork et al., J. Am. Chem. Soc., vol. 75, pp. 4373-4374 (1953).
Lester et al., Chemical Abstracts, vol. 61, 5705h-5707f (1964).

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