Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-10-11
2008-10-14
Desai, Rita (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C514S301000
Reexamination Certificate
active
07435819
ABSTRACT:
The present invention relates to new compounds directly increasing kinase activity of p90 ribosomal S6 kinase 1 (RSK1), a pharmaceutical composition comprising them as active ingredient, a use thereof to prevent or treat hepatic fibrosis or cirrhosis, and a method for preventing or treating hepatic fiborsis or cirrhosis, comprising administering a therapeutically effective amount of the composition to mammal.
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Kang et al., ‘Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation’ In: FASEB Journal, 2002, 16(14), pp. 1988-1990.
Kang et al., ‘The anti-fibrogenic effect of a pharmaceutical composition of oltipraz and DDB’ In: Archives of Pharmacal Research, 2002, 25(5), pp. 655-663.
Kang et al., The Anti-Fibrogenic effect of a Pharmaceutical Composition of [5-(2-Pyrazinyl)-4-menthyl-1,2-dithiol-3-thione (Oltipraz) and Dimethl-4,4′-dimethoxy-5,6,5′,6′-demethylene dioxybiphenyl- 2,2′-dicarboxylate (DDB), Archives of Pharmacal Research, vol. 25, No. 5, pp. 655-663, May 14, 2002.
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Choi Kwang-Do
Kim Jin-Wan
Kim Sang-Geon
Ko Mvong-Suk
Lee Sang-Ho
Birch & Stewart Kolasch & Birch, LLP
CJ Cheiljedang Corp.
Desai Rita
Mabry John
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