4,5,6,7-tetrahydro-[1,2]dithiolo[4,3-C] pyridine-3-thione...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S301000

Reexamination Certificate

active

07435819

ABSTRACT:
The present invention relates to new compounds directly increasing kinase activity of p90 ribosomal S6 kinase 1 (RSK1), a pharmaceutical composition comprising them as active ingredient, a use thereof to prevent or treat hepatic fibrosis or cirrhosis, and a method for preventing or treating hepatic fiborsis or cirrhosis, comprising administering a therapeutically effective amount of the composition to mammal.

REFERENCES:
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patent: WO-01/76604 (2001-10-01), None
patent: WO-03/066058 (2003-08-01), None
Gompper et al Angew. Chem. Int. Eng. Ed. 1967, 6, 366-367.
F. Z. Dorwald Side Reactions in Organic Synthesis: A Guide to Successful Synthesis Design 2005, Wiley-VCH Verlag GmbH and Co. KGaA, Wienheim.
Beers, M. H. The Merck Manual of Medical Information, 2nd Ed., Merck Research Laboratories, Merck and Co. Inc. Whitehouse Station, NJ, 2003.
Kang et al., ‘Oltipraz regenerates cirrhotic liver through CCAAT/enhancer binding protein-mediated stellate cell inactivation’ In: FASEB Journal, 2002, 16(14), pp. 1988-1990.
Kang et al., ‘The anti-fibrogenic effect of a pharmaceutical composition of oltipraz and DDB’ In: Archives of Pharmacal Research, 2002, 25(5), pp. 655-663.
Kang et al., The Anti-Fibrogenic effect of a Pharmaceutical Composition of [5-(2-Pyrazinyl)-4-menthyl-1,2-dithiol-3-thione (Oltipraz) and Dimethl-4,4′-dimethoxy-5,6,5′,6′-demethylene dioxybiphenyl- 2,2′-dicarboxylate (DDB), Archives of Pharmacal Research, vol. 25, No. 5, pp. 655-663, May 14, 2002.
Kang et al., Oltipraz regenerates cirrhotic liver through CCAAT enhancer binding protein-mediated stellate cell inactivation, The FASEB Journal, vol. 16, pp. 1988-1990, Dec. 2002.

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