4-[4-(Thiazolyl-amino)benzyl]-2,3-dioxopiperazine derivatives, a

Details 4-[4-(Thiazolyl-amino)benzyl]-2,3-dioxopiperazine derivatives, a 4-[4-(Thiazolyl-amino)benzyl]-2,3-dioxopiperazine derivatives, a

1982-02-22

1984-05-15

Daus, Donald G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

544 55, 544 60, 544 96, 544121, 544295, 544360, 544366, 544368, 544369, 544370, 544372, 544373, 4242484, 424250, 424251, C07D24106, A61K 3141

Patent

active

044489633

ABSTRACT:
A 1-(4-aminobenzyl)-2,3-dioxopiperazine derivative represented by the formula: ##STR1## and an acid addition salt thereof have excellent carcinostatic activity but a low toxicity. Therefore, said compounds are useful as medicines and also as intermediates.

REFERENCES:
patent: 4110327 (1979-08-01), Saikawa et al.
Hori et al., Chem. & Pharm. Bulletin, vol. 29, (3), pp. 684-698, (1981).
Hori et al., Chem. & Pharm. Bulletin, vol. 29, (6), pp. 1594-1605, (1981).

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